Periodontal Disease / Systemic Inflammation

Oral inflammation as a marker of sleep-related physiologic stress.

  • Relationship of Stress, Distress, and Inadequate Coping Behaviors to Periodontal Disease.

    Genco RJ, Ho AW, Grossi SG, Dunford RG, Tedesco LA.

    Demonstrates that physiologic stress and autonomic dysregulation contribute to periodontal disease progression, supporting a systemic rather than purely local model.

    [Journal of Periodontology, 1999]

  • Association of Obstructive Sleep Apnea with Periodontitis: a Systematic Review.

    Loke YK, Brown JW, Kwok CS, Niruban A, Myint PK.

    Systematic review showing a significant association between obstructive sleep apnea and periodontal disease, reinforcing shared inflammatory and hypoxic pathways.

    [Journal of Clinical Periodontology, 2015]

  • Obstructive Sleep Apnea and Periodontal Disease: a Novel Association?

    Gunaratnam K, Taylor B, Curtis B, et al.

    Identifies higher prevalence and severity of periodontal disease in patients with OSA, suggesting sleep-related breathing disorders as a risk modifier for periodontal health.

    [Journal of Clinical Sleep Medicine, 2009]

  • Sleep-Disordered Breathing and Periodontal Disease: the Role of Inflammation.

    Sanders AE, Essick GK, Beck JD, et al.

    Demonstrates that sleep-disordered breathing is associated with periodontal inflammation independent of traditional periodontal risk factors.

    [Journal of Periodontology, 2015]

  • Is There an Association Between Obstructive Sleep Apnea Syndrome and Periodontal Disease?

    Nizam N, Basoglu OK, Tasbakan MS, Lappin DF, Buduneli N.

    Shows increased periodontal inflammation and altered inflammatory biomarkers in patients with OSA.

    [Clinical Oral Investigations, 2016]

  • Systemic Effects of Periodontitis: Epidemiology of Periodontal Disease and Cardiovascular Disease.

    Beck JD, Offenbacher S.

    Classic paper linking periodontal inflammation with atherosclerosis and cardiovascular disease, reinforcing the airway–inflammation–cardio axis.

    [Journal of Periodontology, 2005]

  • Results from the Periodontitis and Vascular Events (PAVE) Study.

    Offenbacher S, Beck JD, Moss K, et al.

    Demonstrates shared inflammatory pathways between periodontal disease and cardiovascular events, supporting periodontal status as a systemic health marker.

    [American Heart Journal, 2009]

Link List

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https://pubmed.ncbi.nlm.nih.gov/10368067/
https://pubmed.ncbi.nlm.nih.gov/25644429/
https://pubmed.ncbi.nlm.nih.gov/19968009/
https://pubmed.ncbi.nlm.nih.gov/25936429/
https://pubmed.ncbi.nlm.nih.gov/26194510/
https://pubmed.ncbi.nlm.nih.gov/15948690/
https://pubmed.ncbi.nlm.nih.gov/19181398/